| 摘要 |
1-(Pyridinyloxy)-3-(indolylalkylamino)- 2-propanols, novel cardiovascular agents having vasodilator activity and a range of adrenergic beta-receptor blocking action, are prepared by any one of three routes that comprise a novel general process. The general process comprises coupling a hydroxyl- or halogen- substituted pyridine with a suitable halogen- or hydroxyl-substituted propanol or incipient propanol intermediate; and the products of these couplings are also novel. In the preferred of the three coupling routes, product 1-(pyridinyloxy)-3-(indolyl- alkylamino)-2-propanols are formed directly; in the other two coupling routes further processing of the coupling products is required to form the 1-(pyridinyloxy)-3-(indolylalkylamino)- 2-propanols. Preferred compounds bear an amide or cyano substituent in the 3-position of the pyridine ring. |
