A process is disclosed for purifying gamma interferon from various contaminants resulting from disruption of the cell in which the interferon was produced. The process provides for sequential removal of (a) nucleic acids, (b) negatively charged contaminating proteins, (c) positively charged contaminating proteins and (d) low and high molecular weight impurities.
申请公布号
US4751078(A)
申请公布日期
1988.06.14
申请号
US19850751706
申请日期
1985.07.03
申请人
NAGABHUSHAN, TATTANAHALLI L.;TROTTA, PAUL P.;LE, HUNG V.;SEELIG, GAIL F.;KOSECKI, ROBERT A.;SCHERING CORP
发明人
NAGABHUSHAN, TATTANAHALLI L.;TROTTA, PAUL P.;LE, HUNG V.;SEELIG, GAIL F.;KOSECKI, ROBERT A.