发明名称 |
Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid |
摘要 |
In accordance with the present invention an orally active monosulfactam antibiotics having a crystalline structure and thereby improved stability are disclosed. The antibiotics comprise the dierythromycin (M(+)=erythromycin.H(+)) salt or the dicholine (M(+)=HOCH2CH2N(+)(CH3)3) salt of the acid (M(+)=H(+)) having the formula <IMAGE> that is, [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy )-3-azetidinyl]-amino]-2-oxoethylidene]amino]oxy]acetic acid.
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申请公布号 |
US4751220(A) |
申请公布日期 |
1988.06.14 |
申请号 |
US19860944283 |
申请日期 |
1986.12.19 |
申请人 |
E. R. SQUIBB & SONS, INC. |
发明人 |
PARKER, W. LAWRENCE;COHEN, EDWARD M.;KOSTER, WILLIAM H. |
分类号 |
A61K31/425;A61P31/04;C07C215/40;C07D417/12;C07H17/08;(IPC1-7):C07D403/12;A61K31/71 |
主分类号 |
A61K31/425 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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