| 摘要 |
<p>Process for the preparation of 5-hydroxyethylsulfonyl-2-aminophenol (ethers) of the formula (I) <IMAGE> (I) wherein R denotes a hydrogen atom or a C1-C4-alkyl group and R1 denotes a hydrogen atom or an alkyl or alkoxy group with in each case 1-4 carbon atoms, which comprises condensing 5-chloro(or bromo)-2-nitrophenols, or alkyl ethers thereof, of the formula (II) <IMAGE> (II) in which R and R1 have the abovementioned meanings and X denotes a chlorine or bromine atom, with thioglycol to give 2-nitrophenol(ether) 5-hydroxyethyl-sulfides of the formula (III) <IMAGE> (III) wherein R and R1 have the abovementioned meanings, oxidizing these to give 5-hydroxyethylsulfonyl-2-nitrophenol (ethers) <IMAGE> (IV) and reducing the latter to give compounds of the above formula (I).</p> |
