摘要 |
PURPOSE:To obtain an optically active pantolactone useful as a production intermediate for calcium D-pantothenate having bioactivity, in high yield and workability, by carrying out optical resolution of DL-pantolactone using an optically active N,N-disubstituted-phenylalaninol, etc., as a resolution agent. CONSTITUTION:An optically active N,N-disubstituted, N-monosubstituted or unsubstituted phenylalaninol of formula (both of R<1> and R<2> are H or methyl or R<1> is H and R<2> is isopropyl, 2-methylpropyl, n-hexyl, cyclopentyl, etc.) is used as a resolution agent and is made to react with DL-pantolactone or free pantoic acid derived from DL-pantolactone or a mineral acid salt of the optically active phenylalaninol compound is made to react with an alkali salt of DL- pantoic acid. The obtained mixture of diastereomer salts is separated by taking advantage of solubility difference and the obtained diastereomer is decomposed to obtain the objective compound.
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