| 摘要 |
Catechols of formula (IV) <CHEM> where R1 and R2 are each selected from hydrogen, halogen, cyano, -COOH (and derivatives thereof such as unsubstituted or substituted amides) alkyl, aryl and cycloalkyl (which alkyl, aryl and cycloalkyl groups may be substituted), comprising supplying a compound of formula (V) <CHEM> to a culture of a mutant strain of a benzene-metabolising microorganism which contains a cis-benzene glycol dehydrogenase. The dihydrodiol (V) is preferably obtained, without product isolation, by a microbial process from a compound of formula (VI) <CHEM> employing a mutant strain of a benzene-metabolising microorganism which contains a dioxygenase. |
