发明名称 |
ASSAY TECHNIQUE |
摘要 |
"ASSAY TECHNIQUE" An assay technique is disclosed for the qualitative and/or quantitative detection of a chemical, biochemical or biological species in a sample. The technique comprises (a) coating at least a predetermined part of a pre-formed surface on a substrate with a thin film of a material capable of binding the species to be assayed, the pre-formed surface being optically active with respect to radiation at least over a predetermined band of wavelengths; (b) contacting the coated surface with the sample; and (c) observing the optical properties of said pre-formed surface in order to determine a qualitative and/or quantitative change in optical properties as a result of the binding of the species onto said thin film of material. The optical properties of the pre-formed surface may be observed before and after step (b) in order to determine any change in optical properties, or they may be monitored during step (b). The pre-formed surface is preferably a grating. An article for use in the above technique is also disclosed, and comprises a substrate carrying said pre-formed surface which in turn is coated with the receptive material for the species to be assayed. |
申请公布号 |
CA1237645(A) |
申请公布日期 |
1988.06.07 |
申请号 |
CA19830443968 |
申请日期 |
1983.12.21 |
申请人 |
ARES SERONO NV |
发明人 |
LAYTON, DEREK G.;SMITH, ALAN M.;FISHER, JOHN H.;PETTIGREW, ROBERT M.;PETTY-SAPHON, SATHAM |
分类号 |
G01N33/543;C12Q1/00;G01N;G01N21/17;G01N21/21;G01N21/41;G01N21/47;G01N21/75;G01N33/545;G01N33/553 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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