发明名称 |
Process of isolating vinblastine from the plant catharanthis roseus |
摘要 |
This invention relates to a chemical process of producing an antitumor alkaloid. More particularly, it relates to a method of isolation of vinblastine from Catharanthus roseus, comprising the steps of: extracting C. roseus leaves with an acidified aqueous solution; raising the pH and extracting an alkaloid mixture with an organic solvent; chromatographing a solution of the alkaloid mixture over dextran and silica gel columns to obtain vinblastine containing fractions for isolation.
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申请公布号 |
US4749787(A) |
申请公布日期 |
1988.06.07 |
申请号 |
US19860922514 |
申请日期 |
1986.10.23 |
申请人 |
HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC. |
发明人 |
GUANASEKERA, SARATH P. |
分类号 |
C07D519/00;A61K36/24;C07D519/04;(IPC1-7):C07D519/04 |
主分类号 |
C07D519/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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