| 摘要 |
<p>A method and means for providing functional equivalents to organs wherein cells are grown on polymer scaffolding using cell culture techniques followed by transfer of the polymer-cell scaffold into a patient at a site appropriate for attachment, growth and function, after growth and vascularization. Once the structure is implanted and vascularization takes place, the resulting organ is a blend of the parenchymal elements of the donated tissue and vascular and matrix elements of the host. A key element of the method is the design and construction of the polymer scaffold using a material and shape that provides for attachment and growth of the cells such that an adequate exchange of nutrients, wastes and gases occurs by diffusion even within the inner layers of the cells, until such time as implantation and vascularization occur.</p> |
