| 摘要 |
<p>Cephalosporin compounds having a 3-position substituent of the formula (I) are described: -CH2-Y-Q (I) wherein Y is a bond or a linking group -NR<4>-Y'-, -O-Y'-, -S-Y'- wherein R<4> is hydrogen, various optionally substituted alkyl groups, alkenyl, alkanoyl or alkanesulphonyl, and Y' is a bond or various optionally substituted alkylene groups; and Q is a benzene ring (optionally fused to a further benzene ring so forming a naphthyl group or optionally fused to a 5 or 6 membered heterocyclic aromatic group containing 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur), said benzene ring being substituted by groups R<1> and R<2> which are ortho with respect to one another, wherein R<1> is hydroxy or an in vivo hydrolysable ester thereof and R<2> is hydroxy, an in vivo hydrolysable ester thereof, carboxy, sulpho, hydroxymethyl, methanesulphonamido or ureido; or Q is a group of the formula (II) or (III): <CHEM> wherein M is oxygen or a group NR<3> wherein R<3> is hydrogen or C1-4 alkyl; ring Q being further optionally substituted. The use of such compounds as antibacterial agents is described as are processes for their preparation and intermediates therefor.</p> |
