| 摘要 |
This invention relates to new lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties. The present new compounds are of the formula: <IMAGE> and salts thereof; wherein Ar is phenyl, naphthyl or sulfur, oxygen or nitrogen heterocyclic; X is O, S, NR5, or a chemical bond; R is H, lower alkoxy, aryloxy, hydroxy, lower alkyl, aryl or lower aralkyl; R1 and R2 are independently hydrogen, hydroxy, lower alkoxy, lower alkyl, aryl, aryloxy, lower aralkyl, lower aralkoxy, formyl, lower alkanoyl, benzoyl, and lower aralkanoyl; R3 and R4 are independently hydrogen, halogen, hydroxy, lower alkoxy, aryloxy, lower aralkoxy, trifluoromethyl, lower carbalkoxy, carboxy, cyano, nitro, lower alkyl, lower alkenyl, lower alkynyl, aryl or lower aralkyl; R5 is H, lower alkyl, lower aralkyl or aryl; R6 is hydroxy or hydroxy-substituted lower alkyl; n and m are independently 0, 1, 2 or 3.
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