Mixed carboxylato platinum (II) complexes

摘要

PCT No. PCT/SU84/00001 Sec. 371 Date Sep. 4, 1985 Sec. 102(e) Date Sep. 4, 1985 PCT Filed Jan. 23, 1984 PCT Pub. No. WO85/03296 PCT Pub. Date Aug. 1, 1985.Novel platinum(II) carboxylatocomplexes of the following general formula: <IMAGE> wherein R is tetrahydrofurfuryl or cyclo-CnR''2n-1, R'' is H, an alkyl, hydroxyl, n=3-6; R' is -CH2-, -CH2-CH2-, -CH(OH)-, -CH(OH)-CH2-, -CH(OH)-CH(OH)-. These compounds possess a clearly pronounced antitumor activity and are readily soluble in water. A process for preparing these compounds comprises reacting K [PtCl3NH3] with KI, followed by treatment of the reaction mixture with tetrahydrofurfurylamine or an alicyclic amine and treatment of the resulting mixture of complexes with a silver salt of the formula: Ag2(OOC-R'-COO), wherein R' is as identified above.