| 摘要 |
PURPOSE:To easily obtain the titled compound from a raw material available at a low cost, in two steps in high yield using an industrially valuable process, by oxidizing methacrylic acid or its ester with ozone and hydrogenating the reaction product using a palladium catalyst at a specific temperature. CONSTITUTION:Methacrylic acid or a methacrylic acid ester is dissolved in an alcohol solvent such as methanol to a concentration of 0.1-40wt%. The solution is oxidized with preferably 1.05-1.5mol of ozone based on 1mol of the methacrylic acid or its ester and the obtained reaction liquid is hydrogenated at <=15 deg.C, preferably <=0 deg.C in the presence of a palladium catalyst such as Pd/C, Pd/alumina, etc., to obtain the objective compound. The content of supported palladium in the catalyst is 0.1-10wt%. The produced compound is useful as an important intermediate in a metabolic pathway, synthetic raw material for various pharmaceuticals, agricultural chemicals perfumes, etc., synthetic raw material for various chemicals, etc. |
