| 摘要 |
<p>Calcium chelating compounds having a decreased affinity for calcium following illumination and of the formulae
<CHEM>
wherein:
A is -NO2 or -H;
R<1> is -H(unless R<2> is H), -CH3 or other alkyl, -F, -Cl or -Br;
R<2> is -H(unless R<1> is H), -CH3 or other alkyl, -F, -Cl, -Br, or C1-C4 alkoxy;
R<3>, R<4> and R<5> are independently -H, OH, NR<6>R<7>, or alkoxy, or
R<3> and R<4> together are -OCH2O- or -OCH2CH2O- and R<5> is -H, OH, NR<6>R<7>, or alkoxy, or
R<4> and R<5> together are -OCH2O- or OCH2CH2O- and R<3> is -H, OH, NR<6>R<7>, or alkoxy;
X is -OH, alkoxy, -Cl, -Br, -NR<6>R<7>, -OCOCH3, -OCOCF3, -OCOCH2NH2, -OPO3H, or -OSO2CH3;
R<6> and R<7> are independently -H, methyl or ethyl;
D is O, N, NH, or N alkyl;
Q is a double bond when D is N and a single bond otherwise;
R<8> is H and R<9> is H or
R<8> and R<9>, together with heteroatom D, the carbon adjacent R<8>, and the phenyl ring adjacent to R<9>, form a quinoline ring system (D=N, Q=double bond); and
W is -H, -OH, alkoxy or -NHR<6>, the compound optionally being as a physiologically acceptable salt or ester thereof.</p> |
