发明名称 |
AMINOGUANIDINE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF |
摘要 |
<p>The invention relates to new aminoguanidine derivatives of the general formula (I), wherein R1, R2 and R3 each represent hydrogen or halogen atom, C1-4 alkyl, nitro, trifluoromethyl or C1-4 alkoxy group, R4 and R5 represent a C1-4 alkyl group, furthermore NR4R5 may form a 5 to 7 membered saturated heterocyclic group containing either one or two nitrogen atoms or a nitrogen and an oxygen atom and being optionally substituted by one or two methyl, hydroxymethyl or hydroxyethyl groups, R6 and R7 each represent a hydrogen atom, normal or branched C1-4 alkyl or C2-4 alkenyl group, and to their pharmaceutically acceptable acid addition salts as well as to a process for the preparation thereof. The new compounds of the invention possess valuable antiarrhythmic activity and are devoid of the undesired circulatory side effects of the known antiarrhythmic compounds.</p> |
申请公布号 |
CA1237129(A) |
申请公布日期 |
1988.05.24 |
申请号 |
CA19840469862 |
申请日期 |
1984.12.12 |
申请人 |
BIOGAL GYOGYSZERGYAR |
发明人 |
ERCZI, ISTVAN;MAROSFALVI, JENOE;RABLOCZKY, GYOERGY;VARRO, ANDRAS;KUHAR, MARIA NEE KUERTHY;ELEKES, ISTVAN;SZATMARY, LASZLO;JASZLITS, LASZLO |
分类号 |
C07C281/16;A61K31/155;A61K31/40;A61K31/445;A61K31/495;A61K31/535;A61K31/5375;A61K31/55;A61P9/06;C07C281/10;C07D211/10;C07D265/30;C07D295/14;C07D295/215;(IPC1-7):C07C133/10;C07D211/34;C07D295/20 |
主分类号 |
C07C281/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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