2-AMINO-3-KARBETOXIAMINO-6-(P-FLUOR-BENSYLAMINO)-PYRIDIN-MALEAT, FORFARANDE FOR FRAMSTELLNING AV DETTA OCH ETT LEKEMEDEL MED ANALGETISK OCH/ELLER ANTIFLOGISTISK EFFEKT

摘要

There is prepared 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate of the formula The compound has antiphlogistic and analgesic properties in the same manner as the known hydrochloride salt. In contrast to the hydrochloride 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate can be produced without a disturbing blue coloration. This maleate generally is formed from a mixture of two crystal modifications A and B, whereby there is especial advantageous in regard to isolation as well as the galenical preparations a mixture entriched in modification A (60 to 90% modification A).