发明名称 |
PHARMACEUTICAL COMPLEX OF IBUPROXAM AND BETA-CYCLODEXTRIN |
摘要 |
A new inclusion complex of ibuproxam with beta-cyclodextrin is described, which is prepared by adding ibuproxam to a boiling aqueous solution of beta-cyclodextrin, stirring the reaction mixture at the boiling temperature, cooling to a temperature of 0 DEG to 5 DEG C and isolating the title complex. The analgesic, antipyretic and antiinflammatory propeties of the inclusion complex of ibuproxam with beta-cyclodextrin are equivalent to those of ibuproxam alone, but owing to its better water-solubility the complex can be more easily formulated into pharmaceutical forms. |
申请公布号 |
AU8117387(A) |
申请公布日期 |
1988.05.19 |
申请号 |
AU19870081173 |
申请日期 |
1987.11.12 |
申请人 |
LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O., |
发明人 |
JANKO ZMITEK;JENNY MILOVAC;ZDRAVKO KOPITAR;MIRJAM ZORZ;BORIS RUSJAKOVSKI |
分类号 |
C08B37/16;A61K31/165;A61K47/00;A61K47/48;A61P25/04;A61P29/00;C07C67/00;C07C239/00;C07C259/06;C08B37/00 |
主分类号 |
C08B37/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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