NOVEL PYROLIDINEAMIDE DERIVATIVE HAVING ANTI-PROLYL ENDOPEPTIDASE ACTIVITY

摘要

A novel pyrrolidineamide derivative that exhibits inhibitory activity toward prolyl endopeptidase and its use as an inhibitor against said enzyme are provided. The pyrrolidineamide of the invention has the following general formula: wherein R<1> is benzyloxycarbonyl or a group of the formula: (wherein m is an integer of from 1 to 5) and R<2> is hydroxy, acyloxy or a group of the formula: (wherein R<3> and R<4> independently are a hydrogen atom, a halogen atom, a lower alkyl or a lower alkoxy). Pharmaceutical compositions comprising such derivatives are also provided together with processes for the production of the derivatives. The use of the derivatives for the manufacture of medicaments of therapeutic value is also provided.