发明名称 |
A PROCESS FOR THE PRODUCTION OF(1,1-DITHIEN-(3)-YL-1-HYDROXY-(3)-PROPYL)-(1-PHENYL-1-HYDROXY-(2)-PROPYL)-AMINE AND(1,1-DITHIEN-(3)-YL-(1)-PROPEN-(3)-YL)-(1-PHENYL-(2)-PROPYL)-AMINE |
摘要 |
[1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl]-[1-phenyl-1-hydroxy-(2)-prop yl]-amine is prepared by condensing thien-(3)-yl lithium with a beta -halogen propionic acid alkyl ester of the formula <IMAGE> (II) where R is a lower alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50 DEG C. to form a compound of the formula <IMAGE> (III) which is then reacted with 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound. The product cn be converted to [1,1-dithien-(3)-yl-(1)-propen-(3)-yl]-[1-phenyl-(2)-propyl]-amine by dehydration. |
申请公布号 |
ZA7800173(B) |
申请公布日期 |
1978.10.25 |
申请号 |
ZA19780000173 |
申请日期 |
1978.01.11 |
申请人 |
DEGUSSA |
发明人 |
NUBERT I;KLEEMANN A;KIEL R |
分类号 |
C07D333/14;A61K31/382;C07D333/16;C07D333/20 |
主分类号 |
C07D333/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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