| 摘要 |
Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula, R1-A1-S-Z, wherein Z denotes -B-A2, R1 is H or an acyl group, A1 is a carboxylic acid containing at least one amino or imino -N-, A2 is a carboxylic acid containing at least one amino or imino -N- or a lower alkyl ester or amide thereof, B is a 2-4 carbon backbone chain in mercapto linkage to S which includes a carbonyl or sulfonyl group joined in carboxamido or sulfonamido linkage, respectively, to A2. Preferably A2 includes a 4-6 membered C-N ring or a 5 membered ring of one N, one S and 3 C atoms.
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