SUBSTITUTED 1-PYRIDYLOXY-3-INDOLYLALKYLAMINO-2- PROPANOLS, PREPARATION, AND USE THEREOF

摘要

1-(Pyridinyloxy)-3-(indolylalkylamino)-2-propanols, novel cardiovascular agents having vasodilator activity and a range of adrenergic beta-receptor blocking action, are prepared by any one of three routes that comprise a novel general process. The general process comprises coupling a hydroxyl- or halogensubstituted pyridine with a suitable halogen- or hydroxylsubstituted propanol or incipient propanol intermediate; and the products of these couplings are also novel. In the preferred of the three coupling routes, product 1-(pyridinyloxy)-3- (indolylalkylamino)-2-propanols are formed directly; in the other two coupling routes further processing of the coupling products is required to form the 1-(pyridinyloxy)-3-(indolyl-alkylamino)-2-propanols. Preferred compounds bear an amide or cyano substituent in the 3- position of the pyridine ring.