| 摘要 |
There is described a process for preparing a dihydroxy compound of the formula <CHEM> or a physiologically acceptable ether or ester thereof, or a physiologically acceptable acid addition salt of the dihydroxy compound or of the ether or ester thereof; wherein R<1> and R<2> are independently C1-C4 alkyl, or combine to form C4-C6 polymethylene, -CH2CH(CH3)CH2CH2- or -(CH2)2O(CH2)2-; which process comprises acylating a compound of the formula <CHEM> in the presence of aluminum chloride or aluminum bromide with an acylating agent of the formula <CHEM> wherein R<4> is chloro or bromo; and reacting the product with a sulfur compound chosen from the group consisting of methionine and compounds of the formula X-S-Y wherein X is hydrogen or unbranched C1-C4 alkyl, and Y is C1-C4 alkyl or phenyl. |
