| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R represents H or trityl; R1 and R2 represent methyl or phenyl; R3 represents tertiary butyl or dimetylphenylmerhyl). USE:An intermediate for synthesis of gangliosides. PREPARATION:For example, a ceramide compound expressed by formula II is treated with trityl chloride in pyridine to form a trityl derivative, and reacted with a compound expressed by the formula R1R2R3SiCl [example; dimethyl (trimethylmethylphenyl)silyl chloride, etc.] in dimethylformamide to afford a compound expressed by formula III (Ph represents phenyl; Me represents methyl). Then the compound is hydrolyzed in a methylene chloride-methanol mixed solvent to afford the compound expressed by formula I.
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