| 摘要 |
PURPOSE:To obtain the titled compound as an intermediate for an antibacterial agent, by reacting esters of 7-acylamidedesacetoxycephalosporanic acid with an imino halide-forming agent in the presence of an aniline homologue, followed by reaction with a lower alcohol and hydrolysis thereof. CONSTITUTION:Esters of 7-acylamidedesacetoxycephalosporanic acid expressed by formula I (R<1> represents phenyl-acetyl or pyhenyloxyacetyl; -COOR<2> represents esterified carboxyl) are reacted with an imino halide-forming agent (preferably phosphorus oxychloride, etc.) in an inert solvent (preferably methylene chloride, chloroform, etc.) in the presence of an aniline homologue (example; dimethylaniline, etc.). Then the product is reacted with a 1-7C alcohol and subjected to hydrolysis within an acidic region (example; pH=1) to give the aimed compound expressed by formula II.
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