PROCESS FOR THE PREPARATION OF 1-ALPHA-HYDROXY DEHYDROEPIANDROSTERONE

摘要

1. Process for the microbiological manufacture of 1 alpha-hydroxydehydroepiandrosterone, characterized by bringing together dehydroepiandrosterone or a derivative thereof with a microorganism of the species Penicillium oxalicum or Aspergillus terreus, which is capable of 1 alpha-hydroxylating dehydroepiandrosterone or a derivative thereof, or with mycelium isolated from a culture of the said microorganisms or with an enzyme extract prepared in a manner known per se from the culture solution or the mycelium at a point in time at which the carbon source of the culture medium is almost completely consumed.