| 摘要 |
NEW MATERIAL:An antitumor ingredient SPF-PCO-30 having the following physicochemical properties. Elementary analysis(%); C, 37.1.-39.3; H, 5.4-6.4; N, 3.5-4.8; O, 50.5-45.7; Ash, 3.5-3,8; decomposition point; changed to brown at 185 deg.C, black at 255 deg.C and decomposed; [alpha]<20>=30-80 deg. (C=1.00); pH, 5.5-5.8 as 0.1% aqueous solution; color of material; white-slightly yellow; color reaction; positive or Lowry reaction, Biuret reaction, ninhydrin reaction, anthrone sulfuric acid reaction and cysteine sulfuric acid reaction and negative to orcin reaction; molecular weight; >=10,000 (gel filtration method); soluble in water, slightly soluble or insoluble in methanol, ethanol, n-prophanol, acetone, etnyl ether, chloroform, ethyl acetate, etc. USE:An antitumor agent. PREPARATION:Bacteria strains of the genus Streptococcus such as Streptococcus pyogenes ATCC 21060, etc., are incubated preferably anaerobically at pH 6.1-7.2 and 35-37 deg.C for 2-20hr. |
