Conjugated ketone compounds in preventing platelet thrombosis

摘要

Conjugated ketone compounds of the formula: <IMAGE> wherein Ar is naphthyl, furyl, thienyl, or phenyl optionally bearing one or more substituents selected from the group consisting of chlorine, bromine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, trifluoromethyl and methylenedioxy, R1 is C1-C6 alkyl, C3-C5 alkenyl, C3-C6 cycloalkyl, C7-C8 aralkyl or adamantyl, R2 is C1-C6 alkyl, C3-C5 alkenyl or C3-C6 cycloalkyl, or when R1 and R2 are taken together with the nitrogen atom to which they are attached, they form a heterocyclic amino group containing up to 8 carbon atoms, A is straight or branched C1-C3 alkylene, N-[4-(p-chlorophenyl)-4-oxo-2-trans-butenyl]morpholine and N-[4-(p-methoxyphenyl)-4-oxo-2-trans-butenyl]piperidine being excluded, and their non-toxic salts, which are useful as blood platelet anti-aggregative agents.