| 摘要 |
1-(Aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl- alpha , alpha -diaryl-pyrrolidine, piperidine and homopiperidineacetamides and acetonitriles having the formula: …<CHEM>… wherein:… n is zero, one or two;… X is oxygen or sulphur;… Z is …<CHEM>… p is 0 to 5 inclusive with the proviso that when Z is …<CHEM>… p is at least one;… Y is aminocarbonyl or cyano;… Ar<1> and Ar<2> are 2,3 or 4-pyrido, phenyl or substituted phenyl;… R is hydrogen or loweralkyl;… R<1>, R<2> and R<3> are hydrogen, cycloalkyl, loweralkyl, phenyl, substituted phenyl, phenyl-loweralkyl, and R<2> and R<3> taken with the adjacent nitrogen may form a heterocyclic residue, (including diastereoisomers when possible) and pharmaceutical salts; are disclosed as having cardiac antiarrhythmic activity. |
