发明名称 |
ALPHA-ALKYL POLYOLEFINIC CARBOXYLIC ACIDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF PSORIASIS |
摘要 |
Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula <IMAGE> in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH2,NHR2 or NR2R2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis. |
申请公布号 |
DE3376068(D1) |
申请公布日期 |
1988.04.28 |
申请号 |
DE19833376068 |
申请日期 |
1983.06.28 |
申请人 |
RORER INTERNATIONAL (OVERSEAS) INC. |
发明人 |
LOEV, BERNARD;CHAN, WAN-KIT;JONES, HOWARD |
分类号 |
A61K31/22;A61K31/16;A61K31/165;A61K31/19;A61K31/20;A61K31/215;A61K31/23;A61P17/00;C07C57/26;C07C67/00;C07C69/608;C07C401/00;C07C403/00;C07C403/20;(IPC1-7):C07C175/00 |
主分类号 |
A61K31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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