| 摘要 |
This invention relates to a process for the treatment of synthetic plastic, hydrophobic, transparent, intraocular lenses to avoid trauma which causes protein adhesion to occur on the surface of the lens thereby causing endothelial cell damage and corneal deterioration. The process includes the first step of cross-linking the surface of the synthetic plastic, hydrophobic, transparent, intraocular lens by treating the lens with a stream of gas containing from about 5-100% by weight hydrogen of a low pressure of about 0.5-5 Torr in the presence of an A.C. electrical discharge. The second step involves treating such cross-linked surface with hydroxyl radicals, thereby to hydrophilize the surface. The hydrogen may be pure or a component of an inert gas mixture, e.g. in helium. The hydroxyl radicals may be generated in a variety of ways, from low pressure water vapor by electric corona discharge, direct current discharge, alternating current discharge, microwave discharge, and radiofrequency discharge; from aqueous hydrogen peroxide by photolysis and radiolysis, or modified Fenton's reagent using Ti3+, V4+, Cr2+, or Fe2+ ions, or by electrolysis of oxygen to form aqueous hydrogen peroxide in the presence of the same ions. The product is a synthetic plastic, hydrophobic, transparent, intraocular lens having a permanently hydrophilized surface, which does not cause trauma in the eye when utilized as an intraocular lens following surgery. Previous intraocular lenses do not retain hydrophilicity, the surface reverting to hydrophobicity with time.
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