Interfuranylene prostacyclins

摘要

The invention relates to novel interfuranylene-prostacyclin derivatives of the general formula (I) <IMAGE> (I) wherein R1 stands for hydrogen or a straight or branched chain C1-6 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group; R2 stands for hydrogen, a C1-4 alkanoyl or benzoyl group, a monosubstituted benzoyl, trialkylsilyl or an alkoxyalkyl group; R3 stands for a straight or branched chain C1-6 alkyl group, a phenyl group optionally substituted by halogen or by a C1-4 alkyl group, a heteroaryl group optionally substituted by halogen or by a C1-4 alkyl group or a cycloalkyl group; A stands for an ethylene or for a cis- or trans-vinylene or -C 3BOND C- group; B means a chemical bond, a -CHR5-, -CHR5-CH2- or a -CH2-O- group: and R5 means hydrogen or a C1-4 alkyl group. The compounds of the formula (I) can be used therapeutically as platelet aggregation inhibiting, anti-thrombotic, hypotensive and anti-antherosclerotic agents; they are much more stable than the natural prostacyclin derivatives.