PROCESS OF 2-(1-PENTYL-3-QUANIDINO-4-(2-METHYL-4-INIDAZOLYL)THIAZOLE AND THEIR CRYSTALINE DIHYDROCHLORIDE TRIHYDRATE

摘要

The title cpds. of formula (I) and their pharmaceutically acceptable acid addn. salts are prepd. by reacting 2-guanidino-4(2-alkyl-4- imidazolyl)-thiazole with amine of formula RNH2 in the presence (or absence) of inert solvent at 50-150 deg. C. In the formulas, R= benzyl or C1-5 alkyl; R1= C1-5 alkyl. (I) have a good antiulcer activity.