4-Hydroxy-2-oxo-1-pyrrolidinyl-acetamide prodn.

摘要

Prodn. of 4-hydroxy-2-oxo-1 -pyrrolidinylacetamide (I) is effected by (a) treating an alkyl 4-alkoxy-2-oxo -3-pyrroline-1-acetate of formula (II) either with an anhydrous acid or with MeSiCl3 in the presence of an alkali metal iodide to form an alkyl 2,4-dioxo-1 -pyrrolidinylacetate (III); (b) reducing (III) with NaBH4 to form an alkyl 4-hydroxy-2-oxo-1-pyrrolidinylacetate (IV); and (c) reacting (IV) with NH3c. In thormulae R1 = Me or Et; R2 = 1-4C alkyl. Pref. step (a) is effected with MeSiCl3 and NaI in MeCN or with HCl gas in anhydrous HOAc.