Substituted piperazinyl oxindol compounds and cardiotonic compositions containing the same

摘要

An oxindol compound of the formula (I) <IMAGE> (I) wherein A represents a lower alkylene group; R represents a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group, a phenoxy-lower alkyl group, a benzoyl-lower alkyl group, a lower alkoxycarbonyl group, a lower alkanoyl group, a benzoyl group which may be substituted with 1 to 3 of a lower alkyl group, a lower alkoxy group and a halogen atom on the benzene ring thereof, or a benzoyl group which is substituted with a lower alkylenedioxy group on the benzene ring thereof; and m and n, which may be the same or different, each represents an integer of 0 or 1, with proviso that when n is an integer of 1, then m is an integer of 1, when A is an ethylene group and m is an integer of 1, then R should not be 3,4,5-trimethoxybenzoyl group, and when A is a group of the formula: -C(R1)(R2)-(where R1 and R2 are, the same or different, a hydrogen atom or a lower alkyl group) and m is an integer of 1, then R should not be a hydrogen atom; or its pharmaceutically acceptable salt, composition containing the compound and processes for preparing the same are disclosed. The compound is useful as a cardiotonic agent.