Process for the preparation of sodium amoxycillin

摘要

Sodium amoxycillin, of use for example by parenteral administration, is prepared by: (a) suspending amoxycillin trihydrate in a mixture comprising an aprotic organic solvent and a lower alcohol; (b) solubilizing the amoxycillin trihydrate by the addition of a low molecular weight amine of the group of cyclic or heterocyclic aliphatics; (c) adding to such solution the sodium salt of diethyloxalacetic acid, agitating the reaction mixture at a temperature of from -10 DEG C. to ambient temperature and finally isolating the sodium amoxycillin by filtration after its precipitation in the reaction medium by the addition of an aprotic organic solvent.