FRAMSTAELLNING AV (1R,5S,6S)-2 -SUBSTITUERADE TIO-6-/(R)-1-HYDROXIETYL/-1-METYL-KARBAPENEM-2 -KARBOXYLSYRADERIVAT.

摘要

Novel carbapenem compounds, (1R,5S,6S)-2-substituted thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylic acid derivatives. These carbapenem compounds are represented by the following formula having a beta-coordinated methyl group introduced into the 1-position and a 4-pyrazolizinylthio group or a 6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-ylthio group introduced into the 2-position. In the formula, R<1> represents a radical of the formula and R<2> is a hydrogen atom or an anion charge. They have antibacterial activity, and are used for prevention and treatment of bacterial infections as antibacterial agents. A process for producing these carbapenem compounds is also provided.