发明名称 |
CEPHALOSPORIN DERIVATIVES, METHODS OF PRODUCTION THEREOF AND PROPHYLACTIC AND THERAPEUTIC AGENTS FOR BACTERIAL INFECTION |
摘要 |
1. A cephalosporin derivatives of the general formula <IMAGE> (I) wherein R1 is an alpha -, beta - or gamma -amino acid residue (bonded by the ester linkage), which may optionally be substituted by one or two lower alkyl groups at the amino group thereof, R2 is an 1-alkanoyloxyalkyl, 1-alkoxycarbonyloxyalkyl, phthalidyl or 5-methyl-1,3-dioxolen-2-on-4-ylmethyl group, R3 is a carbamoyloxymethyl group, which may optionally be substituted by one or two lower alkyl groups, or a heterocyclothiomethyl group, which may optionally be substituted by one or more appropriate substituents, and R4 is a hydrogen atom or a hydroxy group, or its non-toxic salt are found to be useful as orally administrable antibiotics having broad antimicrobial activities against both gram-positive and gram-negative bacteria. |
申请公布号 |
DE3375787(D1) |
申请公布日期 |
1988.04.07 |
申请号 |
DE19833375787 |
申请日期 |
1983.10.15 |
申请人 |
KYOTO PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
KAKEYA, NOBUHARU;NISHIZAWA, SUSUMU;TAMAKI, SATOSHI;KITAO, KAZUHIKO |
分类号 |
C07D501/36;A61K;A61K31/545;A61K31/546;A61P31/04;B60J10/08;C07D;C07D501/04;C07D501/24;C07D501/32;C07D501/34;C07D501/44;C07D501/46;C07D501/54 |
主分类号 |
C07D501/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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