Arylthio piperidinamide of (4-quinolinylamino)benzoic acid and S-oxidized derivatives

摘要

This invention provides a piperidine compound of the formula: <IMAGE> wherein R1 is hydrogen or trihalomethyl, R2 is hydrogen or protected carboxy, R3 is heterocyclic group or aryl which may be halogen substituted, and X is -S-, <IMAGE> -O-, -NH- or lower alkylene which may be hydroxy substituted, and pharmaceutically acceptable salt thereof, These compounds possess hypotensive activity and are useful as anti-hypertensive agents. The invention further relates to processes for the preparation of these compounds and pharmaceutical compositions comprising compounds of the above formula.