| 摘要 |
PCT No. PCT/JP84/00018 Sec. 371 Date Sep. 27, 1984 Sec. 102(e) Date Sep. 27, 1984 PCT Filed Jan. 26, 1984 PCT Pub. No. WO84/02902 PCT Pub. Date Aug. 2, 1984.A novel prostacyclins expressed by the following formula (1) <IMAGE> (I) wherein a symbol between the 2-position and 3-position indicates single bond or double bond; G indicates -CO2R5 or -CONR6R7 in which R5 is a hydrogen atom, C1-C10 alkyl group, substituted or unsubstituted alicyclic group, substituted or unsubstituted phenyl (C1-C2) alkyl group, tri (C1-C7) hydrocarbon-silyl group, or one equivalent cation, R6 and R7 are identical or different and each representing a hydrogen atom, or C1-C10 alkyl group, or R6 and R7 are substituted or unsubstituted five to six-membered ring which may join together with a nitrogen atom to which they are linked and further contain a hetero atom; R1 indicates a hydrogen atom, or methyl group; R2 indicates an unsubstituted C3-C8 alkyl group substituted or unsubstituted alicyclic group, or substituted C1-C5 alkyl group substituted by substituents selected from phenyl, phenoxy, C1-C6 alkoxy and C5-C6 cycloalkyl group, which substituents may be substituted; and R3 and R4 are identical or different, each indicating a hydrogen atom, C2-C7 acyl group, tri (C1-C7) hydrocarbon-silyl group, or a group which forms an acetal linkage together with the oxygen atom of the hydroxyl group. The prostacyclins has an excellent pharmacological activity such as platelet aggregation inhibiting action, and is extremely useful for medicine such as antithrombotic drug and antiarteriosclerotic drug.
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