FOERFARANDE FOER FRAMSTAELLNING AV FARMAKOLOGISKT AKTIVA 1,2-DIHYDROPYRIDO/3,4-B/PYRAZINER.

摘要

1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess antifungal and anticancer activity. The compounds have the structure: wherein x has a value of 1, 2 or 3; R1 is a lower alkyl group, R2 has the meaning as defined in the description and R3 and R4 are either both hydrogen or one is hydrogen and the other is a lower alkyl group. Processes and intermediates for the preparation of compounds of formula I are disclosed as well as pharmaceutical compositions containing compounds of formula I