CATECHOL DERIVATIVES, AND PREVENTIVE AND REMEDIAL PREPARATIONS FOR REGRESSIVE DISORDERS IN THE CENTRAL NERVOUS SYSTEM CONTAINING THE SAME

摘要

Catechol derivatives which relate to the production of nerve growth factor in particular tissues of the brain are disclosed, as are methods for their synthesis, data on their physiological activity, and data on the toxicity of these derivatives. Examples of preparation for their administration are also disclosed. The disclosed derivatives provide preventive and remedial effects for regressive disorders in the central nervous system including senile dementia of Alzheimer type; a preparation for this purpose includes a catechol derivative having the formula: wherein R is two hydrogen atoms, two acyl groups, a -CO- group, -CO.CO- group, or -C(CH3)2- group, and wherein R1 and R2 are each independently a hydrogen atom or lower alkyl group.