PROCESS FOR THE PREPARATION OF 5,6,7 8- TETRAHYDROFOLIC ACID

摘要

A process for the preparation of 5,6,7,8tetrahydrofolic acid which comprises dissolving and/or suspending folic acid or dihydrofolic acid in an aqueous solution containing an inorganic base, and bringing the resulting solution or suspension into contact with hydrogen in the presence of a noble metal catalyst while maintaining its pH at 5-9, thereby catalytically hydrogenating the folic acid or dihydrofolic acid into 4,5,6,7-tetrahydrofolic acid.