Glutamic acid derivatives and pharmaceutical compositions for the treatment of central nervous system disorders

摘要

A pharmaceutical compound of the formula: in which n is 1 or 2, R<1> is -CO2H, R<2> is hydrogen or C1-4 alkyl and R<3> is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-4 alkyl, optionally substituted phenyl C2-10 alkenyl, (optionally substituted phenyl)2-C1-4 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted C3-7 cycloalkyl-C1-4 alkyl or optionally substituted C3-7 cycloalkyl-C2-10 alkenyl, or R<2> and R<3>, together with the carbon atom to which they are attached, form an optionally substituted c4-7 cycloalkyl group; or a salt or ester thereof other than the compounds gamma -propylidene -L- glutamic acid, gamma -ethylidene-L-glutamic acid and gamma -methylidene -L- glutamic acid.