PROCESS FOR PRODUCING DIHYDR-PYRIDINE DERIVATIVES

摘要

Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: …… or a pharmaceutically acceptable acid addition salt thereof, wherein… n is an integer from 0 to 8;… Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond;… R1 and R2 are each independently, A1, A2, A3 or A4 where A1 is -(CH2)m(CHOH)pCH2OH;… A2 is -(CH2)qCH(3-r)[(CH2)sOH]r;… A3 is -(CH2)qCH(3-r)[(CH2)PCOOR3]r; and… A4 is -(CH2)mCOOR3; where… m is an integer from 1 to 8;… p is an integer from 0 to 4;… q is an integer from 0 to 8;… r is 2 or 3;… s is an integer from 1 to 4; and… R3 is H or alkyl of 1 to 18 carbon atoms;… R4 is -NO2, -CF3, or halo; and… R5 is lower alkyl or -CH2CH2OCH3.