| 摘要 |
NEW MATERIAL:An antiviral active substance. Molecular weight: <=1,000; solubility: easily soluble in water or methanol, slightly soluble or insoluble in ethanol, n-butanol, ethyl acetate, 2-butanol, 1,4-dioxane, etc.; Rf value on paper chromatography [Toyo filter paper No.526; developing solvent=pyridine/n-butanol/distilled water (1:1:1)]:0.75-0.78(22-25 deg.C); neutrality. USE:An antiviral agent. Having both virucidal action and inhibitory action on multiplication of virus, and low cell toxicity. PREPARATION:The whole plant of Hypericum erectum harvested at the flowering time is directly extracted with ethanol at 0-100 deg.C or extracted after drying. Extraction is repeated for 2-3 times, the extract is evaporated to dryness under reduced pressure, blended with a heterogeneous mixed solvent of chloroform/ methanol/water, the methanol/water layers are separated, evaporated to dryness, partitioned, and purified, to give an antiviral active substance.
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