| 摘要 |
PURPOSE:To obtain a preservation agent effective in maintaining the quality of concentrated erythrocyte liquid having high hematocrit value, by using an L-ascorbic acid-2-phosphoric acid ester (salt), adenine and a specific disaccharide such as maltose, etc., as main components. CONSTITUTION:A concentrated erythrocyte liquid having hematocrit value of >=95% is preserved by mixing with an aqueous solution containing (A) 2.5-25mmol of an L-ascorbic acid-2-phosphoric acid ester or its salt, (B) 0.25-0.375mmol of adenine and (C) 50-100mmol of maltose, mannitol and/or sucrose. A high-quality erythrocyte drug preparation capable of sufficiently keeping the concentration of 2,3-DPG and ATP after long-term storage and free from side effects in transfusion can be produced by mixing and floating an erythrocyte liquid having high hematocrit value in preservation liquid having extremely high stability against autoclave sterilization. |
