| 摘要 |
<p>A method is disclosed for quantitatively measuring the progression of a lesion toward malignant disease by digitizing images of clinical samples of biopsied lesions using a microphotometer that includes a video camera, and a computer that includes a video frame capture board. The digitized image is analyzed to locate the borders of cell nuclei within the captured video image, and one or more chromatin texture features within such nuclei are processed by the computer to arrive at a numerical value. This numerical value is compared to a monotonic progression curve that has been previously established by using the same procedure on known clinical samples ranging from normal tissue to malignant disease. The method can also be used to test the efficacy of chemopreventive drugs and treatments.</p> |
