| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> is formula II-IV, etc., (R<4> and R<5> are lower alkyl or phenylalkyl; R<6> is lower alkyl, hydroxyalkyl, etc.; n is an integer of 4-7); R<2> and R<3> are H, lower alkyl, tetrahydrofurylalkyl, etc.] and salt thereof. EXAMPLE:Diisopropyl [4,5-dipiperidino-1,3-dithilane-2-ilidene]malonate. USE:An agent for activating human or aminal hepatic action and remedy for hepatopathy. PREPARATION:For example, sodium acidic sulfite adduct of glyoxal expressed by formula V is reacted with a compound expressed by the formula R<1>H is a mixed solvent of water with an organic solvent while cooling - at a temperature of 80 deg.C and the resultant reaction product is reacted with a compound expressed by formula VI (M is alkali metal) at -20-60 deg.C. The compound expressed by formula V is normally preferably obtained by reacting glyoxal with sodium bisulfite. |
