Process for the preparation of clausenamide

摘要

A new synthetic route to clausenamide having the formula <IMAGE> has been found. It has been found that a compound of the formula <IMAGE> can be oxidized to provide the stereochemically correctly configured product, clasuenamide. A number of new compounds useful in the total synthesis of clausenamide have also been found. These compounds have the general formula <IMAGE> wherein R is <IMAGE> and CH2OH.