| 摘要 |
(A) 1-Amino-3-phenoxy-2-propanol derivs. of formula (I) and their acid-addn. salts are new where R1 = H or a physiologically hydrolysable ester residue; (a) Z = O, X = bond, R = 3,4-dimethoxyphenyl, R1 = Br, R2 = Me; (b) Z = O, X = O, R = 4-methoxyphenyl, R1 = allyl, R2 = Me; (c) Z = O, X = O, R = 4-methoxyphenyl, R1 = CN, R2 = 4-methoxybenzyl; (d) Z = bond, X = O, R = 4-methoxyphenyl, R1 = Br, R2 = cyclopropylmethyl; (e) Z = bond, X = O, R = 4-methoxyphenyl, R1 = CN, R2 = cyclopropylmethyl; (f) Z = O, X = O, R = 4-methoxyphenyl, R1 = Br, R2 = 4-methoxybenzyl; (g) Z = O, X = bond, R = 3,4-dimethoxyphenyl, R1 = CN, R2 = cyclopropylmethyl; (h) Z = O, X = bond, R = 3,4-dimethoxyphenyl, R1 = Br, R2 = cyclopropylmethyl; (i) Z = O, X = bond, R = 4-methoxyphenyl, R1 = Br, R2 = Me; (j) Z = O, X = O, R = 3,4-dimethoxyphenyl, R1 = H, R2 = cyclopropylmethyl; (k) Z = O, X = bond, R = 3,4-dimethoxyphenyl, R1 = allyl, R2 = Me; (l) Z = O, X = O, R = 4-methoxyphenyl, R1 = allyl, R2 = cyclopropylmethyl; (m) Z = O, X = O, R = 4-methoxyphenyl, R1 = Br, R2 = cyclopropylmethyl; (n) Z = O, X = O, R = phenyl, R1 = Br, R2 = cyclopropylmethyl; (o) Z = O, X = O, R = 4-methoxyphenyl, R1 = CN, R2 = 2-methylpropyl. (B) Intermediates of formula (II) and (III) are also new. USE - (I) are alpha- and beta-adrenergic receptor blockers useful for treating coronary heart disease, myocardial infarct, hypertension, migraine, glaucoma, thyreotoxicosis, arrhythmia, etc.
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